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Is tailored therapy based on antibiotic susceptibility effective?
Jie Pan, Zhengchao Shi, Dingsai Lin, Ningmin Yang, Fei Meng, Lang Lin, Zhencheng Jin, Qingjie Zhou, Jiansheng Wu, Jianzhong Zhang, Youming Li
《医学前沿(英文)》 2020年 第14卷 第1期 页码 43-50 doi: 10.1007/s11684-019-0706-8
关键词: tailored triple therapy tailored bismuth-containing quadruple therapy traditional bismuth-containing quadruple therapy antibiotic susceptibility testing eradication rates
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《医学前沿(英文)》 2017年 第11卷 第2期 页码 287-292 doi: 10.1007/s11684-017-0510-2
Castleman disease (CD) is an uncommon non-clonal lymphoproliferative disorder with unknown etiology. No standard therapy is recommended for relapsed/refractory CD patients, thus requiring development of novel experimental approaches. Our cohort of three adult patients with multicentric CD (MCD) were treated with refractory to traditional chemotherapy lenalidomide-containing regimens (10–25 mg lenalidomide perorally administered on days 1–21 in 28-day cycle) as second- to fourth-line treatment. Partial remission was achieved in first plasma-cell CD patient, who relapsed seven months after autologous hematopoietic stem cell transplantation and then failed to respond to four cycles of chemotherapy. Partial remission was obtained in second patient with CD and polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes syndrome. Third case showed complete remission with complete disappearance of pleural effusion and ascites and normalization of platelet count. To conclude, encouraging clinical responses were achieved in cohort of three patients with lenalidomide-based regimen, though long-term efficacy remains to be observed. We propose further investigation of therapeutic potential of this drug in treating MCD.
Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a
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《医学前沿(英文)》 2017年 第11卷 第2期 页码 191-202 doi: 10.1007/s11684-017-0512-0
Primary hepatic carcinoma (PHC) is a common malignant tumor in China. Cancer is comprehensively treated with various therapeutic regimes, including traditional Chinese medicine (TCM). TCM has been widely used to improve the quality of life, delay the time of cancer progression, and prolong the median survival time. This systematic review with meta-analysis aimed to assess the effect of TCM combined with Western therapy on primary hepatic carcinoma. A comprehensive literature search was conducted in six databases, including CNKI, VIP, Wan-Fang Database, CBM, PubMed, and Cochrane library. A total of 44 randomized controlled trials (RCTs) involving 3429 participants suffering from PHC were selected. Meta-analysis results indicated that the overall effect of TCM and Western integrative treatment on PHC was higher than that of Western intervention alone, which can postpone tumor recurrence and metastasis and prolong the overall survival time of patients with PHC. Although the obtained evidence remained weak because of the poor methodological quality of the included studies, this review provided relevant data supporting the efficacy and safety of TCM combined with Western therapies. In future research, individual RCT studies should incorporate accepted standards for trial design and reporting, proper outcome indicators according to international standards, blinding in allocation concealment, and valid follow-up periods.
关键词: traditional Chinese medicine primary hepatic carcinoma meta-analysis
《医学前沿(英文)》 2022年 第16卷 第5期 页码 736-744 doi: 10.1007/s11684-021-0870-5
关键词: pneumoconiosis randomized controlled trials traditional Chinese medicine
Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives
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《医学前沿(英文)》 2012年 第6卷 第1期 页码 67-78 doi: 10.1007/s11684-012-0176-8
Antitumor angiogenic therapy has been shown promising in the treatment of several advanced cancers since the approval of the first antiangiogenic drug Avastin in 2004. Although the current antiangiogenic drugs reduce the density of tumor blood vessels and result in tumor shrinkage at the early stage of treatment, recent studies have shown that antiangiogenic therapy has transient and insufficient efficacy, resulting in tumor recurrence in patients after several months of treatment. Blockage of blood and oxygen supplies creates a hypoxic and acidic microenvironment in the tumor tissues, which fosters tumor cells to become more aggressive and metastatic. In 2001, Jain proposed tumor vascular normalization as an alternative approach to treating cancers based on the pioneering work on tumor blood vessels by several other researchers. At present, normalizing the disorganized tumor vasculature, rather than disrupting or blocking them, has emerged as a new option for anticancer therapy. Preclinical and clinical data have shown that tumor vascular normalization using monoclonal antibodies, proteins, peptides, small molecules, and pericytes resulted in decreased tumor size and reduced metastasis. However, current tumor vascular normalizing drugs display moderate anticancer efficacy. Accumulated data have shown that a variety of vasculogenic/angiogenic tumor cells and genes play important roles in tumor neovascularization, growth, and metastasis. Therefore, multiple-targeting of vasculogenic tumor cells and genes may improve the efficacy of tumor vascular normalization. To this end, the combination of antiangiogenic drugs with tumor vascular normalizing therapeutics, as well as the integration of Western medicine with traditional Chinese medicine, may provide a good opportunity for discovering novel tumor vascular normalizing drugs for an effective anticancer therapy.
关键词: angiogenesis vasculogenesis neovascularization tumor vasculature normalization traditional Chinese medicine
《能源前沿(英文)》 doi: 10.1007/s11708-023-0893-5
关键词: copper bismuthate photocathode ligand growth strategy dense film PEC
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《医学前沿(英文)》 2014年 第8卷 第3期 页码 368-375 doi: 10.1007/s11684-014-0360-0
This study aimed to evaluate the efficacy of comprehensive therapy based on traditional Chinese medicine (TCM) patterns on older patients with chronic obstructive pulmonary disease (COPD) through a four-center, open-label, randomized controlled trial. Patients were divided into the trial group treated using conventional western medicine and Bu-Fei Jian-Pi granules, Bu-Fei Yi-Shen granules, and Yi-Qi Zi-Shen granules based on TCM patterns respectively; and the control group treated using conventional western medicine. A total of 136 patients≥65 years completed the study, with 63 patients comprising the trial group and 73 comprising the control group. After the six-month treatment and the 12-month follow-up period, significant differences were observed between the trial and control groups in the following aspects: frequency of acute exacerbation (P≤0.040), duration of acute exacerbation (P = 0.034), symptoms (P≤0.034), 6-min walking distance (6MWD) (P≤0.039), dyspnea scale (P≤0.036); physical domain (P≤0.019), psychological domain (P≤0.033), social domain (P≤0.020), and environmental domain (P≤0.044) of the WHOQOL-BREF questionnaire; and daily living ability domain (P≤0.007), social activity domain (P≤0.018), depression symptoms domain (P≤0.025), and anxiety symptoms domain (P≤0.037) of the COPD-QOL. No differences were observed between the trial and control groups with regard to FVC, FEV1, and FEV1%.
关键词: chronic obstructive pulmonary disease older adult clinical trial Bu-Fei Jian-Pi granules Bu-Fei Yi-Shen granules Yi-Qi Zi-Shen granules
《能源前沿(英文)》 2021年 第15卷 第3期 页码 781-790 doi: 10.1007/s11708-021-0782-8
关键词: bismuth ferrate ferroelectric polarisation photoelectrochemical (PEC) water splitting graphene oxide (GO) high orientation
《化学科学与工程前沿(英文)》 2023年 第17卷 第6期 页码 784-794 doi: 10.1007/s11705-022-2278-4
关键词: bismuth-ellagic acid in situ encapsulation enzyme@MOF biocomposites
传统中医药治疗类风湿性关节炎——从经验医学到循证医学 Review
潘胡丹, 肖瑶, 王婉莹, 任汝通, 梁丽娴 , 刘良
《工程(英文)》 2019年 第5卷 第5期 页码 895-906 doi: 10.1016/j.eng.2019.01.018
类风湿关节炎(RA)是一种常见的自身免疫性疾病,病因难以捉摸。常规和生物疾病缓解药物有时会失效或仅产生部分反应。中药(TCM)长期以来一直在中国用作RA的治疗方法,并在世界范围内得到越来越多的接受。传统上,中医治疗以中医辨证论治为指导。但是,它们仍然依赖于中医理论和医生进行经验实践
关键词: 中药,类风湿关节炎,循证治疗,展望
《化学科学与工程前沿(英文)》 2022年 第16卷 第7期 页码 1125-1138 doi: 10.1007/s11705-021-2116-0
关键词: high-exposure (110) facet oxygen vacancy-rich BiOI-110/DCN heterojunction photocatalytic degradation visible-light-response
How to judge the association of postmenopausal hormone therapy and the risk of breast cancer
Ling XU
《医学前沿(英文)》 2010年 第4卷 第3期 页码 290-293 doi: 10.1007/s11684-010-0093-7
关键词: breast cancer postmenopausal hormone therapy unopposed estrogen therapy combined estrogen-progestin therapy
Jian Wang, Wen Zou
《医学前沿(英文)》 2011年 第5卷 第2期 页码 123-126 doi: 10.1007/s11684-011-0124-z
Extractive desulfurization of model fuels with a nitrogen-containing heterocyclic ionic liquid
《化学科学与工程前沿(英文)》 2022年 第16卷 第12期 页码 1735-1742 doi: 10.1007/s11705-022-2167-x
关键词: extractive desulfurization nitrogen-containing heterocyclic ionic liquid reduced density gradient analysis desulfurization selectivity
Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19
《医学前沿(英文)》 doi: 10.1007/s11684-023-1040-8
关键词: traditional Chinese medicine COVID-19 SARS-CoV-2 clinical evidence-based study mechanism integrated traditional Chinese and Western medicine
标题 作者 时间 类型 操作
Is tailored therapy based on antibiotic susceptibility effective?
Jie Pan, Zhengchao Shi, Dingsai Lin, Ningmin Yang, Fei Meng, Lang Lin, Zhencheng Jin, Qingjie Zhou, Jiansheng Wu, Jianzhong Zhang, Youming Li
期刊论文
Salvage therapy with lenalidomide containing regimen for relapsed/refractory Castleman disease: a report
null
期刊论文
Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a
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期刊论文
Clinical efficacy of comprehensive therapy based on traditional Chinese medicine patterns on patients
期刊论文
Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives
null
期刊论文
Surface modification by ligand growth strategy for dense copper bismuth film as photocathode to enhance
期刊论文
Effects of comprehensive therapy based on traditional Chinese medicine patterns on older patients with
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期刊论文
Spontaneous polarization enhanced bismuth ferrate photoelectrode: fabrication and boosted photoelectrochemical
期刊论文
Enzyme@bismuth-ellagic acid: a versatile platform for enzyme immobilization with enhanced acid-base stability
期刊论文
Crystal design of bismuth oxyiodide with highly exposed (110) facets on curved carbon nitride for the
期刊论文
How to judge the association of postmenopausal hormone therapy and the risk of breast cancer
Ling XU
期刊论文
Practices, challenges, and opportunities: HIV/AIDS treatment with traditional Chinese medicine in China
Jian Wang, Wen Zou
期刊论文